Shameless Person
noun, な adjective
恥 is a "disgrace." If you 知らず then you don't know something. In this case, you don't know disgrace, and a person who doesn't know disgrace is a shameless person, because they don't care what disgraces them and what doesn't.
はじしらず
The reading is 恥 and 知る put together.
あの俺の兄貴は恥知らずの嘘つきだ。何の事だかサッパリ分からないなんて言ってたくせに、俺のベーコンを平らげたのはアイツだったんだよ。
My brother is such a shameless liar. He told me he had no idea what happened, but he was the one who ate all my bacon.