Tiredness, Fatigue
noun
疲れる is "to get tired." This is the noun version, which makes it tiredness or fatigue. 疲れ is a more casual version of 疲労, so people commonly choose 疲れ over 疲労 in everyday conversation.
つかれ
The reading comes from 疲れる.
ネコは疲れをいやしてくれるよ。
Cats will soothe you when you're tired.
年のせいか、疲れが中々とれないんだよね。
Maybe it's because I'm old, but I can't shake off my fatigue easily.
うちの子は、疲れ知らずで、一日中ずーっと走り回ってられるんです。
Our little boy is tireless and can run around all day long.